1.1.U3 Cell Surface to volume is an important limitation to cell size.

• Outline the activities occurring in the volume and at the surface of the cell.

• Calculate the surface area, volume and SA:V ratio of a cube.

• Explain the benefits and limitations of using cubes to model the surface area and volume of a cell.

• Describe the relationship between cell size and the SA:V ratio of the cell.

• Explain why cells are often limited in size by the SA:V ratio.

• List three adaptations of cells that maximize the SA: volume ratio

Initial Knowledge audit

SA:V notes

Modeling SA:V with cubes

Cube data

A&B:  The unsexiest thing in science (article)

BTB Cube lab

Cube lab data collection form

Iodine into potato cubes lab

Past classes potato lab data

Design a cell lab

Design a cell (old vB version)

SA:V debrief

Limits to cell size CFU

1.4.U1:  Particles move across membranes by simple diffusion, facilitated diffusion, osmosis and active transport.

• Describe simple diffusion.

• Explain two examples of simple diffusion of molecules into and out of cells.

• Outline factors that regulate the rate of diffusion.

Membrane transport (vision learning)

Membrane and distribution (vision learn)

Diffusion virtual simulation

Diffusion across a membrane virtual

Effect of temp on diffusion simulation

Factors affecting the rate of diffusion dry lab

Solute size mini-lab

1.4.U1:  Particles move across membranes by simple diffusion, facilitated diffusion, osmosis and active transport.

• Define osmosis.

• Predict the direction of water movement based upon differences in solute concentration.

1.4.A2:  Tissues or organs to be used in medical procedures must be bathed in a solution with the same osmolarity as the cytoplasm to prevent osmosis. 

• Explain what happens to cells when placed in solutions of the same osmolarity, higher osmolarity and lower osmolarity.

• Outline the use of normal saline in medical procedures.

Osmolarity in medicine

Modeling tonicity activity

Tonicity practice problems:

• Set A

• Set B

• Set C

Case studies:

• Frat hazing death article

• Can water kill case study

• Liam

Death by osmosis lab

Osmotic changes in RBC lab

Egg osmosis labs:

• Simple

• Detailed

• A&B option

Review of osmosis

Diffusion and osmosis CFU

1.4.NOS:  Experimental design- accurate quantitative measurement in osmosis experiments are essential. 

• Define quantitative and qualitative.

• Determine measurement uncertainty of a measurement tool.

• Explain the need for repeated measurements (multiple trials) in experimental design.

• Explain the need to control variables in experimental design

Measurement slides

Rulers for uncertainty practice

Practice with determining uncertainty

1.4.S1:  Estimation of osmolarity in tissues by bathing samples in hypotonic and hypertonic solutions. Practical 2 

• Define osmolarity, isotonic, hypotonic and hypertonic.

• Calculate the percentage change between measurement values.

• Accurately graph mean and standard deviation of data sets.

• Determine osmolarity of a sample given changes in mass when placed in solutions of various tonicities.

Data Based Questions

• Beet roots

• Dialysis tubing

Labs: 

• Osmosis at home labs

• Potato osmosis lab

1.4.U1:   Particles move across membranes by simple diffusion, facilitated diffusion, osmosis and active transport.

• Describe facilitated diffusion.

• Describe one example of facilitated diffusion through a protein channel.

Scitable ion channel reading

Channel Surfing reading and questions

A&B  Vital signs podcast

A&B  This Podcast will Kill you CF

Modeling effects of CF lab

Phet membrane channels 

Passive transport review

1.4.U1:  Particles move across membranes by simple diffusion, facilitated diffusion, osmosis and active transport.

• Compare active transport and passive transport.  

• Explain one example of active transport of molecules into and out of cells through protein pumps.

Active transport yeast lab

Simple co-transport model

1.4.U2:  The fluidity of membranes allows materials to be taken into cells by endocytosis or released by exocytosis. 

• Describe the fluid properties of the cell membrane and vesicles.

• Explain vesicle formation via endocytosis.

• Outline two examples of materials brought into the cell via endocytosis.

• Explain release of materials from cells via exocytosis.

• Outline two examples of materials released from a cell via exocytosis.